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Adenosine triphosphate: established and potential clinical applications.

H J Agteresch1, P C Dagnelie, J W van den Berg

  • 1Department of Internal Medicine II, Erasmus University Rotterdam, The Netherlands.

Drugs
|September 3, 1999
PubMed
Summary

Adenosine triphosphate (ATP) and adenosine show therapeutic potential across various medical fields, including pain management, cardiovascular conditions, and cystic fibrosis treatment. Further research is needed to fully realize their clinical benefits.

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Area of Science:

  • Biochemistry
  • Pharmacology
  • Clinical Medicine

Background:

  • Adenosine triphosphate (ATP) is crucial for cellular metabolism and signaling.
  • Extracellular ATP and its metabolite adenosine influence neurotransmission, muscle function, and vasodilation via P1 and P2 receptors.
  • Ectonucleotidases regulate extracellular nucleotide levels, impacting physiological processes.

Purpose of the Study:

  • To review the diverse clinical applications of ATP and adenosine.
  • To highlight their therapeutic potential in anesthesia, cardiology, pulmonology, and oncology.
  • To identify areas requiring further clinical investigation.

Main Methods:

  • Literature review of clinical studies and applications of ATP and adenosine.
  • Analysis of therapeutic effects in various medical conditions.

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  • Synthesis of evidence for potential clinical benefits.

    • Main Results:

    • Adenosine effectively reduces neuropathic and ischemic pain, decreasing opioid use.
    • ATP and adenosine induce controlled hypotension during surgery and show promise in treating hemorrhagic shock.
    • ATP is an effective pulmonary vasodilator for pulmonary hypertension; ATP and adenosine aid in diagnosing cardiac conditions.
    • Nucleotides improve mucociliary clearance in cystic fibrosis; ATP may inhibit cancer growth and protect against radiation damage.

    Conclusions:

    • ATP and adenosine possess significant therapeutic potential across multiple medical disciplines.
    • Clinical applications in pain management, cardiovascular diseases, and respiratory conditions are promising.
    • Further controlled clinical trials are essential to validate and expand the use of ATP, adenosine, and uridine 5'-triphosphate.