Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Expression pattern of macrophage migration inhibitory factor during embryogenesis.

S Kobayashi1, K Satomura, J M Levsky

  • 1Functional Genomics Unit, Gene Targeting Facility, Bethesda, MD 20892, USA.

Mechanisms of Development
|September 3, 1999
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeted TNF-α Overexpression Drives Salivary Gland Inflammation.

Journal of dental research·2019
Same author

STAT3 Induces Immunosuppression by Upregulating PD-1/PD-L1 in HNSCC.

Journal of dental research·2017
Same author

ENAMEL-LIKE ANTIGENS IN HAGFISH: POSSIBLE EVOLUTIONARY SIGNIFICANCE.

Evolution; international journal of organic evolution·2017
Same author

Conditional TNF-α Overexpression in the Tooth and Alveolar Bone Results in Painful Pulpitis and Osteitis.

Journal of dental research·2015
Same author

Dual induction of apoptotic and autophagic cell death by targeting survivin in head neck squamous cell carcinoma.

Cell death & disease·2015
Same author

From Phenotype to Genotype: Enter Genomics and Transformation of Primary Health Care around the World.

Journal of dental research·2014

Macrophage migration inhibitory factor (MIF) plays a crucial role in embryonic development. Its expression pattern during mouse embryogenesis mirrors tissue specification and organogenesis, suggesting broader functions beyond immunity.

Area of Science:

  • Developmental Biology
  • Immunology
  • Molecular Biology

Background:

  • Macrophage migration inhibitory factor (MIF) was initially identified as a lymphokine with immune functions.
  • Ubiquitous expression of MIF suggests roles beyond the immune system.
  • Understanding MIF's developmental role is crucial.

Purpose of the Study:

  • To characterize the expression pattern of MIF during mouse embryogenesis.
  • To investigate the potential role of MIF in embryonic development.

Main Methods:

  • Detailed characterization of MIF expression.
  • Analysis of MIF expression patterns in developing mouse embryos.

Main Results:

  • MIF expression was observed throughout mouse embryogenesis.

Related Experiment Videos

  • The expression pattern of MIF closely paralleled key developmental processes.
  • MIF expression correlated with tissue specification and organogenesis.

    • Conclusions:

    • MIF is dynamically expressed during mouse embryogenesis.
    • MIF expression patterns suggest a significant role in embryonic development, beyond its known immune functions.
    • Further research is warranted to elucidate MIF's specific developmental mechanisms.