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Mid-sagittal anatomy in late-onset schizophrenia.

P S Sachdev1, H Brodaty

  • 1School of Psychiatry, University of New South Wales, Neuropsychiatric Institute and the Academic Department of Psychogeriatrics, The Prince Henry Hospital, Sydney, Australia.

Psychological Medicine
|September 3, 1999
PubMed
Summary
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This study found no significant differences in corpus callosum or cerebellum size in late-onset schizophrenia (LOS) compared to early-onset schizophrenia (EOS) or healthy controls. A smaller pons size was observed in both schizophrenia groups.

Area of Science:

  • Neuroimaging
  • Psychiatry
  • Neuroanatomy

Background:

  • Midline brain structure abnormalities, including the corpus callosum and cerebellum, are known in early-onset schizophrenia.
  • It remains unknown if similar abnormalities exist in late-onset schizophrenia (LOS).

Purpose of the Study:

  • To investigate mid-sagittal brain region areas, specifically the corpus callosum and cerebellum, in patients with late-onset schizophrenia (LOS).
  • To compare these brain structures between LOS, early-onset schizophrenia (EOS), and healthy controls (NC).

Main Methods:

  • Magnetic resonance imaging (MRI) was used to examine mid-sagittal cross-sectional areas of the corpus callosum and cerebellum.
  • Patients with LOS (N=25) were compared to EOS (N=24) and healthy controls (N=30) matched for age and gender.

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Main Results:

  • No statistically significant differences were found in corpus callosum area or corpus callosum to cerebrum ratios across the LOS, EOS, and NC groups.
  • Cross-sectional cerebellar areas and cerebellum:cerebrum ratios also did not differ among the groups.
  • A smaller brainstem, specifically the pons, was observed in both schizophrenic groups (LOS and EOS) compared to controls.

Conclusions:

  • No abnormalities were detected in the mid-sagittal area of the corpus callosum and cerebellum in either early- or late-onset schizophrenia subjects.
  • The clinical significance of the smaller pontine cross-sectional area requires further investigation and replication using volumetric measures.