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Effect of cromolyn pre-treatment on capsaicin-induced rhinitis in rats
T Baudoin1, L Kalogjera, Z Ferencić
1Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital "Sestre milosrdnice", Vinogradska 29, HR-10000 Zagreb, Croatia.
Abstract:
The effect of cromolyn sodium local pre-treatment on capsaicin-induced rhinitis in rats was studied by analyzing tissue changes due to edema, inflammatory cell infiltration and IgA upregulation. Nasal mucosa samples were stained with hematoxylin-eosin and examined immunohistochemically with monoclonal IgA antibodies. Changes were analyzed at 6, 12 and 72 h after capsaicin treatment and were scored semiquantitatively. Results showed that local cromolyn pre-treatment modified all parameters observed in the nasal mucosa following capsaicin-induced rhinitis in the rats.
