In vitro bactericidal activities of antimicrobial agents and morphologic changes on Prevotella bivia

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H Mikamo1, Y Sato, Y Hayasaki

  • 1Department of Obstetrics and Gynecology, School of Medicine, Gifu University, Gifu, Japan.

Chemotherapy
|September 4, 1999
PubMed

Insights

This study examined antimicrobial effects on Prevotella bivia, common in pelvic inflammatory disease. Cephalosporins, clindamycin, and imipenem showed bactericidal activity, inducing distinct cellular changes in P. bivia.

Area of Science:

  • Microbiology
  • Pharmacology
  • Infectious Diseases

Background:

  • Prevotella bivia is frequently implicated in pelvic inflammatory diseases.
  • Parenteral antimicrobial agents are standard treatments for such infections.

Purpose of the Study:

  • To evaluate the bactericidal activity of cefluprenam, ceftazidime, cefotaxime, clindamycin, and imipenem against Prevotella bivia.
  • To observe in vitro morphological changes induced by these antimicrobial agents in P. bivia.

Main Methods:

  • In vitro susceptibility testing of Prevotella bivia against five antimicrobial agents.
  • Microscopic examination of P. bivia cells following exposure to antimicrobial agents to assess morphological alterations.

Main Results:

  • Cephalosporins (cefluprenam, ceftazidime, cefotaxime) demonstrated bactericidal activity and induced filamentation in P. bivia.
  • Clindamycin and imipenem were also bactericidal, causing spheroblast formation and lysis in P. bivia.
  • Distinct morphological changes were observed for each class of antimicrobial agent tested.

Conclusions:

  • Antimicrobial agents exhibit characteristic effects on Prevotella bivia morphology.
  • Understanding these differential effects may inform treatment strategies for P. bivia infections.

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