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Updated: Oct 19, 2026

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Tc-99m-labeling of modified RNA
C S Hilger1, M C Willis, M Wolters
1Schering AG, Research Laboratories, Berlin, FRG.
Abstract:
The synthesis of Tc-99m-labeled, modified RNA is reported. This new class of radiopharmaceuticals is of potential interest as target specific imaging agents. The preparation of N3S-RNA was achieved by coupling protected MAG2-units to amino modified ON's. The N3S-RNA was Tc-99m-labeled with 90-95% radiochemical yield and specific activities of 37MBq/nmol leading to 1:1-Tc-99m-N3S-aptamers.
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