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Sequence-specific alkylation of DNA by duocarmycin A and its novel derivatives bearing PY/IM polyamides
1Institute for Medical and Dental Engineering, Tokyo Medical and Dental University, Japan.
Nucleosides & Nucleotides
|September 4, 1999
Abstract:
A new class of sequence-specific DNA alkylating agents were developed based on the reactivity of duocarmycin A and the DNA-reading ability of pyrrole-imidazole polyamide. The DNA alkylation sequence specificity by duocarmycin A can be modulated by a variety of pyrrole-imidazole triamides in a predictable manner. Novel hybrids of the segment A of duocarmycin A and pyrrole-imidazole polyamides efficiently and highly selectively alkylated the target base possessing match sequences of Dervan's binding code.