Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[PBSCT and GVHD].

M Hino1, T Yamane, K Ohta

  • 1Department of Clinical Hematology, Osaka City University Medical School.

Rinsho Byori. the Japanese Journal of Clinical Pathology
|September 4, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immunohistochemical identification and characterization of smooth muscle-like cells in idiopathic pulmonary fibrosis.

American journal of respiratory and critical care medicine·1995
Same author

Delineation of producing ability of IgG and IgA subclasses by naive B cells in newborn infants and adult individuals.

Clinical and experimental immunology·1995
Same author

Quantitation of hepatitis C viral RNA in liver and serum samples using competitive polymerase chain reaction.

Journal of clinical pathology·1995
Same author

Randomized study with mitomycin C + 5-fluorouracil+cytosine arabinoside (MFC)+5-fluorouracil, MFC+tegafur and uracil (UFT), and MF+UFT in advanced gastric cancer: interinstitutional differences in a multicenter study in Japan.

Journal of surgical oncology·1995
Same author

[Value of PSA/gamma-Sm ratio (P/S ratio) for diagnosis of prostate cancer in patients with urinary retention].

Nihon Hinyokika Gakkai zasshi. The japanese journal of urology·1995
Same author

Bilateral inguinal scrofuloderma during steroid therapy in a patient with bullous pemphigoid.

The Journal of dermatology·1995
Same journal

[The Role of Laboratory Medicine in Hematopoietic Stem Cell Transplantation "Echocardiogram"].

Rinsho byori. The Japanese journal of clinical pathology·2019
Same journal

[The Significance of Pulmonary Function Testing Before and After Allogeneic Stem Cell Transplantation].

Rinsho byori. The Japanese journal of clinical pathology·2019
Same journal

[Blood Transfusion Inspection].

Rinsho byori. The Japanese journal of clinical pathology·2019
Same journal

[The Role of Clinical Laboratory Technicians at Bone Marrow Transplantation : Blood Test].

Rinsho byori. The Japanese journal of clinical pathology·2019
Same journal

[The Foundation of Allogeneic Hematopoietic Stem Cell Transplantation and the Role of Clinical Laboratory Tests in This Field].

Rinsho byori. The Japanese journal of clinical pathology·2019
Same journal

[How to Interpret Data from Routine Laboratory Tests].

Rinsho byori. The Japanese journal of clinical pathology·2019
See all related articles

Allogeneic peripheral blood stem cell transplantation (PBSCT) offers rapid engraftment but may increase the risk of chronic graft-versus-host disease (GVHD) compared to bone marrow transplantation.

Area of Science:

  • Hematology
  • Immunology
  • Transplantation Medicine

Background:

  • Allogeneic peripheral blood stem cell transplantation (PBSCT) is a growing alternative to allogeneic bone marrow transplantation (BMT).
  • PBSCT facilitates faster engraftment of neutrophils and platelets post-transplant.
  • While T cell infusion is higher in PBSCT, acute graft-versus-host disease (GVHD) incidence and severity are comparable to BMT.

Purpose of the Study:

  • To compare the outcomes of allogeneic PBSCT and BMT.
  • To evaluate the risks associated with PBSCT, particularly regarding graft-versus-host disease.

Main Methods:

  • Comparative analysis of patient data undergoing allogeneic PBSCT versus BMT.
  • Assessment of engraftment times for neutrophils and platelets.

Related Experiment Videos

  • Evaluation of the incidence and severity of acute and chronic graft-versus-host disease.

    • Main Results:

    • Allogeneic PBSCT demonstrates rapid engraftment of neutrophils and platelets.
    • No significant difference in the incidence or severity of acute graft-versus-host disease was observed between PBSCT and BMT.
    • A higher risk of developing chronic graft-versus-host disease was reported following allogeneic PBSCT compared to BMT.

    Conclusions:

    • Allogeneic PBSCT is an effective alternative to BMT, offering faster hematologic recovery.
    • The risk of chronic GVHD is a significant consideration for patients undergoing allogeneic PBSCT.
    • Further research is warranted to mitigate the risk of chronic GVHD in PBSCT recipients.