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Related Experiment Videos

Mandibular lengthening with an implanted motor-driven device: preliminary study in sheep.

O Ploder1, W Mayr, G Schnetz

  • 1Clinic for Oral and Maxillofacial Surgery, Vienna University Medical School, Austria. oliver.ploder@univie.ac.at

The British Journal of Oral & Maxillofacial Surgery
|September 4, 1999
PubMed
Summary

This study introduces a new implantable device for mandibular lengthening using distraction osteogenesis. The device achieved significant bone growth in sheep without external components, showing promise for future clinical applications.

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Area of Science:

  • Oral and Maxillofacial Surgery
  • Biomedical Engineering
  • Regenerative Medicine

Background:

  • Distraction osteogenesis is a proven technique for mandibular lengthening.
  • Current methods often utilize external or intraoral devices, which can pose infection risks and patient discomfort.
  • A fully implantable device offers a potential alternative to overcome these limitations.

Purpose of the Study:

  • To evaluate the efficacy and safety of a novel, fully implantable electromechanical device for mandibular lengthening in a preclinical sheep model.
  • To assess bone regeneration and device performance during distraction osteogenesis without transmucosal components.

Main Methods:

  • A newly designed, fully implantable electromechanical device was used in three sheep following mandibular osteotomy.

Related Experiment Videos

  • The device was screw-fixed to the mandible, with the control unit placed subcutaneously.
  • Magnetic activation allowed for controlled distraction at 0.04 mm/h, totaling 1.0 mm/day over 14 days.

    • Main Results:

    • A maximum mandibular lengthening of 13.6 mm was achieved over 14 days.
    • Radiological and histological evaluations demonstrated membranous and/or cartilaginous bone formation in the callus.
    • No transmucosal activation was required, indicating a potentially reduced infection risk.

    Conclusions:

    • The fully implantable electromechanical device shows potential for effective mandibular lengthening in a preclinical setting.
    • The device facilitated bone regeneration without external hardware, suggesting clinical applicability.
    • Further research is warranted to confirm the long-term clinical usefulness and safety of this innovative device.