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Presentation of protective antigen to the mouse immune system: immune sequelae
E D Williamson1, R J Beedham, A M Bennett
1CBD Sector, DERA, Porton Down, Salisbury, Wilts, UK.
Journal of Applied Microbiology
|September 4, 1999
Abstract:
Protective antigen (PA), the major protective component of the existing vaccine, is a potent immunogen. Protective antigen in alhydrogel induced a high serum IgG titre (> log10 4) in both the C57B16 and Balb/c mouse and the predominant subclass of antibody induced was IgG1, indicating that the response to PA was predominantly Th2 directed. When plasmid DNA encoding PA was used to immunize the Balb/c mouse, a low serum IgG titre was detected (