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Salmonella typhi strain with transmissible multiple resistance.

V Rusu, O Baron-Dorobăţ, S Diamandi

    Zentralblatt Fur Bakteriologie, Parasitenkunde, Infektionskrankheiten Und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie Und Parasitologie
    |May 1, 1976
    PubMed
    Summary
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    This case study details a multidrug-resistant Salmonella Typhi infection. Recovery was achieved after prolonged treatment, highlighting the challenges of antibiotic resistance in typhoid fever.

    Area of Science:

    • Microbiology
    • Infectious Diseases
    • Genetics

    Background:

    • Typhoid fever remains a significant global health concern, often complicated by antimicrobial resistance.
    • The emergence of multidrug-resistant (MDR) Salmonella Typhi poses a therapeutic challenge.

    Observation:

    • A patient presented with typhoid fever caused by MDR Salmonella Typhi.
    • Initial treatment with chloramphenicol and ampicillin showed limited efficacy, with relapses occurring.
    • Two distinct strains of S. Typhi were isolated, differing in their resistance profiles and typability.

    Findings:

    • Resistance markers were successfully transferred from an MDR S. Typhi strain to recipient bacteria via conjugation.
    • The resistance factor (R factor) exhibited an 'fi-' character, potentially influencing phage susceptibility.

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  • The study identified a specific R factor responsible for the multidrug resistance in Salmonella Typhi.

    • Implications:

    • This case underscores the critical need for surveillance of MDR typhoid strains.
    • Understanding R factor transmission is crucial for developing effective treatment and control strategies.
    • The findings have significant implications for public health policies and antibiotic stewardship programs in regions endemic for typhoid fever.