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Synthesis and pharmacological activity of diarylindole derivatives. Cytotoxic agents based on combretastatins
M Medarde1, A C Ramos, E Caballero
1Lab. de Química Orgánica y Farmacéutica. Fac. Farmacia, Salamanca, Spain. medarde@gugu.usal.es
Bioorganic & Medicinal Chemistry Letters
|September 7, 1999
Abstract:
Taking into account the structure of Combretastatins, we have synthesized and assayed for cytotoxic activity of new indole derivatives. Two aryl groups are maintained in the cis orientation required for activity by means of an indole moiety built up on less active ketoderivatives used as starting materials.