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Updated: Aug 7, 2026

Mouse- and Human-derived Primary Gastric Epithelial Monolayer Culture for the Study of Regeneration
Published on: May 7, 2018
Signaling pathways mediating gastrin's growth-promoting effects
1Department of Medicine, MCP Hahnemann University, Philadelphia, PA 19102-1192, USA.
Gastrin, a peptide hormone, stimulates gastric acid and promotes cell growth through various receptors and signaling pathways. Research is ongoing to understand the specific roles of different gastrin forms and their receptors in cell proliferation.
Area of Science:
- Gastroenterology
- Molecular Biology
- Cell Biology
Background:
- The peptide hormone gastrin is crucial for stimulating gastric acid secretion.
- Gastrin also exhibits growth-promoting effects on various target cells via endocrine, paracrine, and autocrine mechanisms.
Purpose of the Study:
- To elucidate the mechanisms and receptors mediating gastrin's growth-promoting actions.
- To understand the signaling pathways involved in gastrin-induced cell proliferation.
Main Methods:
- Identification and characterization of gastrin receptors, including CCKA, CCKB/gastrin receptor, CCKC, and novel high-affinity receptors.
- Analysis of signaling pathways activated by gastrin receptor engagement, such as tyrosine kinases, phospholipase C, and MAPK pathways.
Main Results:
- Gastrin binding to its receptors initiates diverse biochemical events, including kinase activation and intracellular signaling cascades.
- Multiple receptor subtypes bind different forms of gastrin, with varying affinities.
- Signaling pathways for the CCKB/gastrin receptor are well-defined, while others are emerging.
Conclusions:
- Gastrin's mitogenic effects are mediated by specific cell surface receptors.
- Further research is needed to understand the functional significance of gastrin processing intermediates and their specific receptor subtypes and pathways in trophic/mitogenic effects.
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