Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Progress of nuclear oncology].

K Endo1

  • 1Department of Nuclear Medicine, Gunma University School of Medicine, Maebashi, Japan.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|September 9, 1999
PubMed
Summary

Radioactive isotopes, or radionuclides, are crucial in cancer care for both diagnosis and therapy. Different radionuclides like Iodine-131 (131I), Technetium-99m (99mTc), and Fluorine-18 (18F) offer unique benefits in detecting and treating various cancers.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synthesis and preliminary evaluation of [11C]KF15372, a selective adenosine A1 antagonist.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·1995
Same author

Repeating the avidin "chase" markedly improved the biodistribution of radiolabelled biotinylated antibodies and promoted the excretion of additional background radioactivity.

European journal of cancer (Oxford, England : 1990)·1995
Same author

GTP cyclohydrolase I gene in hereditary progressive dystonia with marked diurnal fluctuation.

Neuroscience letters·1995
Same author

Vertical vestibular input to and projections from the caudal parts of the vestibular nuclei of the decerebrate cat.

Journal of neurophysiology·1995
Same author

A tumour-associated cell-surface glycoprotein accompanying p53 overexpression and higher growth potential for gastric cancer.

British journal of cancer·1995
Same author

Expression of C-terminal src kinase in human colorectal cancer cell lines.

Japanese journal of clinical oncology·1995

Area of Science:

  • Nuclear medicine
  • Oncology
  • Radiochemistry

Background:

  • Radionuclides are essential in modern cancer management, produced via cyclotrons or nuclear reactors.
  • Iodine-131 (131I) has a long history in treating thyroid cancer with metastasis.
  • Advancements include Technetium-99m (99mTc) for diagnosis and Fluorine-18 (18F)-FDG for PET imaging in diverse cancers.

Purpose of the Study:

  • To review the applications of various radionuclides in cancer diagnosis and therapy.
  • To highlight the diagnostic superiority of 99mTc over 131I and the development of 99mTc-labeled compounds.
  • To discuss the role of 18F-FDG PET in cancer detection and the therapeutic potential of beta-emitting radionuclides.

Main Methods:

  • Review of established and emerging radionuclide applications in oncology.
  • Discussion of diagnostic imaging agents, including 99mTc-labeled compounds and 18F-FDG PET.
  • Examination of therapeutic radionuclides and targeted radiotherapies.

Main Results:

  • 131I is effective for thyroid cancer treatment, while 99mTc excels in diagnosis.
  • 18F-FDG PET imaging shows excellent results for various cancers like lung, colorectal, lymphoma, and melanoma.
  • Beta-emitting radionuclides show promise for cancer therapy, including targeted therapies and palliative bone pain management.

Conclusions:

  • Radionuclides play a dual role in cancer care, offering advanced diagnostic and therapeutic capabilities.
  • The development of novel radiolabeled agents continues to improve patient outcomes.
  • Specific radionuclides are optimized for different cancer types and stages, including palliative care.

Related Experiment Videos