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Related Experiment Videos

Case report: Macroglobulinemia in a dog.

E B Mejia, S Carman, J H Lumsden

    The Canadian Veterinary Journal = La Revue Veterinaire Canadienne
    |January 1, 1979
    PubMed
    Summary
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    This case study details a six-year-old dog with macroglobulinemia, a rare blood disorder. Treatment involving chemotherapy and blood component removal led to a temporary recovery, highlighting therapeutic options for canine macroglobulinemia.

    Area of Science:

    • Veterinary Medicine
    • Hematology
    • Canine Oncology

    Background:

    • Macroglobulinemia is a rare lymphoproliferative disorder characterized by the overproduction of IgM antibodies.
    • This condition can lead to hyperviscosity syndrome, manifesting with various clinical signs.

    Observation:

    • A six-year-old castrate male Collie cross dog presented with epistaxis, anemia, retinopathy, and high serum viscosity.
    • Diagnostic findings included elevated total serum protein (12 g/dl) with 60% monoclonal beta globulin.
    • Absence of proteinuria, Bence Jones protein, and osteolytic lesions was noted.

    Findings:

    • The canine patient exhibited clinical signs consistent with Waldenström's macroglobulinemia.
    • Chemotherapy combined with plasmapheresis (whole blood withdrawal and packed red cell transfusion) induced a transient clinical remission.

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  • This therapeutic approach managed the hyperviscosity syndrome effectively in the short term.

    • Implications:

    • This case highlights the importance of recognizing and managing macroglobulinemia in dogs.
    • Combined chemotherapy and plasma protein reduction can offer temporary relief from clinical signs.
    • Further research into long-term treatment strategies for canine macroglobulinemia is warranted.