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Phenylethanoid glycosides from Globularia trichosantha.
I Calis1, H Kirmizibekmez, H Rüegger
1Department of Pharmacognosy, Faculty of Pharmacy, Hacettepe University, TR-06100 Ankara, Turkey. acalis@dominet.in.com.tr
Journal of Natural Products
|September 10, 1999
Summary
Five phenylethanoid glycosides were isolated from Globularia trichosantha, including two new compounds. All isolated compounds showed antioxidant activity by scavenging free radicals.
Area of Science:
- Phytochemistry
- Natural Products Chemistry
- Pharmacognosy
Background:
- Globularia trichosantha is a plant species with potential medicinal properties.
- Phenylethanoid glycosides are a class of compounds known for their biological activities.
Purpose of the Study:
- To isolate and characterize phenylethanoid glycosides from Globularia trichosantha.
- To evaluate the antioxidant potential of the isolated compounds.
Main Methods:
- Isolation of compounds using chromatographic techniques.
- Structure elucidation using spectral data (e.g., NMR, MS).
- Antioxidant activity assessment using TLC autographic assays with 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical.
Main Results:
- Five phenylethanoid glycosides were isolated: crenatoside (1), verbascoside (2), trichosanthoside A (3), rossicaside A (4), and trichosanthoside B (5).
- Compounds 3 and 5 were identified as new natural products.
- All five compounds (1-5) exhibited free radical scavenging activity against DPPH radicals.
Conclusions:
- The aerial parts of Globularia trichosantha are a source of diverse phenylethanoid glycosides.
- The newly identified compounds, trichosanthoside A and trichosanthoside B, possess antioxidant properties.
- Phenylethanoid glycosides from this plant hold potential for further investigation as antioxidants.