Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Kininogens are antithrombotic proteins In vivo.

R W Colman1, J V White, S Scovell

  • 1Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, Pa 19140. colmanr@astro.temple.edu

Arteriosclerosis, Thrombosis, and Vascular Biology
|September 10, 1999
PubMed
Summary

Kininogens demonstrate significant antithrombotic effects in vivo, reducing blood clot formation in deficient rats. This suggests kininogen-derived peptides could be a novel antithrombotic strategy.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retention of Placenta.

The Southern medical record·2022
Same author

Osteoarthritis induced by destabilization of the medial meniscus is reduced in germ-free mice.

Osteoarthritis and cartilage·2018
Same author

MDR1 deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation.

Mucosal immunology·2017
Same author

Rifaximin Exerts Beneficial Effects Independent of its Ability to Alter Microbiota Composition.

Clinical and translational gastroenterology·2016
Same author

Review article: the potential mechanisms of action of rifaximin in the management of inflammatory bowel diseases.

Alimentary pharmacology & therapeutics·2015
Same author

C/EBP homologous protein inhibits tissue repair in response to gut injury and is inversely regulated with chronic inflammation.

Mucosal immunology·2014

Area of Science:

  • Biochemistry
  • Physiology
  • Vascular Biology

Background:

  • Kininogens possess antiadhesive, anticoagulant, and profibrinolytic properties.
  • They can inhibit platelet activation at low thrombin concentrations.

Purpose of the Study:

  • To investigate the in vivo antithrombotic properties of kininogens.
  • To assess the role of kininogens in a thrombosis model with limited arterial injury.

Main Methods:

  • A thrombosis model involving endothelial removal was used in Brown-Norway rats.
  • Kininogen-deficient rats (A163T mutation) were compared to wild-type littermates.
  • Laser Doppler was employed to measure blood flow reduction.

Main Results:

Related Experiment Videos

  • Kininogen-deficient rats showed a significantly shorter time to 90% flow decrease (38.4 min) compared to wild-type rats (194 min).
  • Vascular injury was equivalent between groups.
  • No evidence of disseminated intravascular coagulation or excessive fibrinolysis was observed.

    • Conclusions:

    • Kininogens exhibit antithrombotic properties, particularly at low thrombin concentrations.
    • Inhibitory peptides derived from kininogen represent a potential new antithrombotic strategy.