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Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
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Related Experiment Video

Updated: Mar 2, 2026

Novel Assay for Cold Nociception in Drosophila Larvae
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Hot and cold nociception are genetically correlated.

J S Mogil1, S M Adhikari

  • 1Department of Psychology and Neuroscience Program, University of Illinois at Urbana-Champaign, Champaign, Illinois 61820, USA.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|September 10, 1999
PubMed
Summary

Genetic factors influence how mice sense both hot and cold pain. This study found a significant genetic link between responses to noxious heat and cold stimuli in mice, suggesting shared biological pathways.

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Area of Science:

  • Neuroscience
  • Genetics
  • Pain Research

Background:

  • Previous research shows genetic correlations in mouse nociception to heat.
  • The underlying stimulus property (heat vs. general temperature) for this correlation remains unclear.
  • Existing literature on heat and cold pain shows both similarities and differences.

Purpose of the Study:

  • To investigate if genetic correlations in nociception extend to both hot and cold stimuli.
  • To determine if temperature, rather than heat specifically, underlies observed genetic correlations in pain sensitivity.
  • To compare nociceptive responses across multiple inbred mouse strains.

Main Methods:

  • Tested 12 inbred mouse strains for withdrawal sensitivity to hot (47.5°C) and cold (-15°C) water immersion.
  • Compared tail-flick latencies to previously obtained data using a 49°C stimulus.
  • Analyzed heritability and cross-correlation of nociceptive traits.

Main Results:

  • All tested nociceptive traits exhibited substantial heritabilities (0.41–0.50).
  • Significant cross-correlations (r = 0.49–0.77) were observed between strain means for hot and cold nociception.
  • Genetic correlation between hot and cold nociception was demonstrated.

Conclusions:

  • Similar genes likely influence individual differences in both hot and cold nociception in mice.
  • These findings suggest shared physiological mechanisms mediate hot and cold pain perception.
  • The results have implications for understanding pain variability in mammals, including humans.