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Triterpene antioxidants from ganoderma lucidum.

M Zhu1, Q Chang, L K Wong

  • 1Department of Pharmacy, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China. minzhu@cuhk.edu.hk

Phytotherapy Research : PTR
|September 10, 1999
PubMed
Summary

Ganoderma lucidum exhibits significant antioxidant activity. Its terpene fraction, containing ganoderic acids, demonstrated the strongest protective effects against oxidative stress in vitro.

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Area of Science:

  • Pharmacology
  • Natural Products Chemistry
  • Biochemistry

Background:

  • Oxidative stress is implicated in various pathologies.
  • Natural products like Ganoderma lucidum are explored for therapeutic potential.
  • Antioxidant compounds can mitigate cellular damage.

Purpose of the Study:

  • To investigate the antioxidant properties of Ganoderma lucidum.
  • To isolate and identify active compounds responsible for antioxidant effects.
  • To evaluate the efficacy of different Ganoderma lucidum fractions.

Main Methods:

  • Bioassay-guided isolation of active compounds.
  • In vitro antioxidant assays, including erythrocyte membrane oxidation and lipid peroxidation.
  • Chemical characterization of isolated compounds.

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Main Results:

  • Ganoderma lucidum extracts and fractions displayed dose-dependent antioxidant activity.
  • The terpene fraction exhibited superior antioxidant effects compared to the aqueous extract and polysaccharide fraction.
  • Key compounds identified in the terpene fraction include ganoderic acids A, B, C, D, lucidenic acid B, and ganodermanontriol.

Conclusions:

  • Ganoderma lucidum possesses potent antioxidant capabilities.
  • Terpene compounds, particularly ganoderic acids, are major contributors to its antioxidant activity.
  • This study supports the use of Ganoderma lucidum as a source of natural antioxidants.