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Gastroprotective effect of propacetamol against cold/restraint stress ulcers in rats
K Marazova1, E Klouchek, A Popov
1Department of Pharmacology, Faculty of Medicine, Faculty Hospital S. Anna, Sofia, Bulgaria.
Background:
Comparative evaluation of propacetamol and morphine on the cold restraint stress ulcers in rats.
Methods:
The present study compared the effects of propacetamol hydrochloride (250 and 500 mg.kg-1 i.p.) and morphine hydrochloride (10 mg.kg-1 i.p.) against gastric mucosal damage induced by cold/restraint stress (4 degrees C for 3 h) in rats. Morphometrical and histomorphological studies were carried out. Mean ulcer number and length were calculated.
Results:
The results show that propacetamol in the lower dose tested decreases the ulcer number and length by 56.4% (p > 0.05) and by 68.94% (p < 0.01). After propacetamol 500 mg.kg-1 the ulcer number and length were found significantly decreased by 74.83% and 83.5%. Marked decrease was found in morphine-pretreated group (-77.03% and -85.09%). The morphometrical results have been confirmed histomorphologically.
Conclusions:
It might be concluded that morphine (10 mg.kg-1) and propacetamol (500 mg.kg-1) are equipotent in their ability to prevent the stress ulceration in rats.