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Spectrophotometric Screening for Potential Inhibitors of Cytosolic Glutathione S-Transferases
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Published on: October 10, 2020

Glutathione reductase activity and flavin concentration in guinea-pig tissues

M Suzuki1, H Muraoka, M Kurata

  • 1Japan Lypophilization Laboratory, Tokyo, Japan.

Experimental Animals
|September 10, 1999
PubMed

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Glutathione, a tripeptide made up of glutamate, cysteine, and glycine, is a critical player in the detoxification of drugs and xenobiotics via a process known as glutathione conjugation or mercapturic acid formation. This phase II biotransformation reaction involves the covalent binding of glutathione to a drug or its metabolite, enhancing the compound's water solubility and enabling its excretion.
Several distinctive characteristics distinguish glutathione conjugation from other phase II...