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[In vitro bactericidal activities of new oral penem, faropenem against the various clinical isolates]

K Matsuzaki1, T Nishiyama, M Hasegawa

  • 1Chemotherapy Division, Mitsubishi-Kagaku Bio-Clinical Laboratories, Tokyo, Japan.

The Japanese Journal of Antibiotics
|September 10, 1999
PubMed

Insights

Faropenem (FRPM) demonstrates potent in vitro antibacterial activity against Gram-positive bacteria and comparable efficacy to new oral cephems against Gram-negative bacteria, suggesting its clinical utility for bacterial infections.

Area of Science:

  • Microbiology
  • Pharmacology
  • Infectious Diseases

Background:

  • Oral beta-lactams are commonly used for bacterial infections.
  • Evaluating new antibiotics like faropenem (FRPM) is crucial for expanding treatment options.
  • Understanding the in vitro activity spectrum of FRPM is essential for its clinical application.

Purpose of the Study:

  • To compare the in vitro antibacterial activity of faropenem (FRPM) with various oral beta-lactams.
  • To determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of FRPM.
  • To assess the bactericidal activity of FRPM against clinical isolates.

Main Methods:

  • Testing FRPM and oral beta-lactams against 15 isolates each of 6 bacterial species.
  • Determining MIC and MBC values for each antibiotic and isolate.
  • Comparing the activity profiles of FRPM and reference antibiotics.

Main Results:

  • FRPM exhibited potent in vitro activity against aerobic and anaerobic Gram-positive bacteria.
  • FRPM showed comparable activity to new oral cephems against Gram-negative bacteria, with lower susceptibility in K. pneumoniae strains.
  • The MBC of FRPM was equal to or within one dilution of the MIC for tested strains, indicating bactericidal activity.

Conclusions:

  • Faropenem (FRPM) possesses excellent in vitro antibacterial and bactericidal activity against clinical isolates.
  • FRPM demonstrates promising efficacy comparable to existing oral beta-lactams.
  • FRPM is suggested to be a clinically useful agent for the chemotherapy of bacterial infections.

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