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Cytokines, nitric oxide, heat shock proteins and virulence in Toxoplasma
C M Miller1, N C Smith, A M Johnson
1Molecular Parasitology Unit, Department of Cell and Molecular Biology, University of Technology, Sydney, Westbourne Street, Gore Hill, New South Wales, Australia 2065. catherine.miller@uts.edu.au
Parasitology Today (Personal Ed.)
|September 11, 1999
Abstract:
Elucidating the factors that play important roles in the expression of virulence by parasites is crucial to understanding disease pathogenesis and to developing control strategies rationally. Here, Kate Miller, Nick Smith and Alan Johnson, using Toxoplasma gondii as a model, argue that the interactions between the immune system and 70 kDa heat shock proteins of apicomplexan parasites profoundly influence parasite virulence.