Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tissue transglutaminase: an enzyme with a split personality.

J S Chen1, K Mehta

  • 1Department of Bioimmunotherapy, University of Texas, M.D. Anderson Cancer Center, Houston 77030, USA.

The International Journal of Biochemistry & Cell Biology
|September 11, 1999
PubMed
Summary

Tissue transglutaminase (tTG) is a multifunctional enzyme involved in protein cross-linking, apoptosis, and signal transduction. Its roles in diseases like Alzheimer's and Parkinson's highlight its physiological significance.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A large chest wall tumour in an asymptomatic 15-year-old girl.

BMJ case reports·2011
Same author

Nanogranular L1(0) FePt-C-Ta2O5 composite media for perpendicular recording applications.

Journal of nanoscience and nanotechnology·2011
Same author

Interlayer exchange coupling effect of L1(0) CoPt based exchange coupled composite media.

Journal of nanoscience and nanotechnology·2011
Same author

NiW/Ru underlayer for CoPt-SiO2 granular perpendicular recording media.

Journal of nanoscience and nanotechnology·2011
Same author

Nanostructured SmCo5 thin films with perpendicular anisotropy formed in a wide range of Sm-Co compositions.

Journal of nanoscience and nanotechnology·2011
Same author

Endoscopic evolution of rectal stercoral ulcer presenting with a large bleeding pseudodiverticulum in a patient with chronic constipation.

Endoscopy·2011

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Background:

  • Tissue transglutaminase (tTG) catalyzes calcium-dependent protein cross-linking, forming stable isopeptide bonds.
  • The precise physiological roles of tTG remain under investigation, despite its involvement in various biological processes.

Purpose of the Study:

  • To review recent findings on the multifunctional enzyme tissue transglutaminase (tTG).
  • To summarize the key features and emerging roles of tTG in biological processes and disease.

Main Methods:

  • Literature review of recent research on tissue transglutaminase (tTG).

Main Results:

  • tTG cross-linking may contribute to cellular apoptosis and the formation of pathological aggregates (e.g., Alzheimer's, Parkinson's).

Related Experiment Videos

  • tTG also binds and hydrolyzes ATP/GTP, acting as a G-protein to activate phospholipase C and mediate signal transduction.
  • tTG's signal transduction capabilities suggest a role in regulating cell cycle progression.

    • Conclusions:

    • Tissue transglutaminase (tTG) is a versatile enzyme with significant implications in cell death, neurodegenerative diseases, and cell cycle regulation.
    • Further research into tTG's functions is crucial for understanding its role in health and disease.