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Published on: February 23, 2014
[Pulmonary complications in adult measles]
1Department of Internal Medicine, Niigata Prefectural Shibata Hospital.
Abstract:
The clinical features of pulmonary complications were evaluated in 15 patients with adult measles diagnosed by clinical and serologic investigations. Of those 15 patients, 12 were admitted because of high fever, sever anorexia and dyspnea. Almost all patients were found to have thrombocytopenia, elevations of LDH and aminotransferase. Pulmonary infiltrates were present in only 2 of the 12 patients (16.7%) on whom chest roentgenograms were performed, but hypoxemia (PaO2 < 70 Torr) were present in 8 of the 12 patients (66.7%). Pulmonary function tests in 8 patients showed mild decrease in VC, moderate decrease in FEV1 and severe decrease in V25. These findings suggest that hypoxemia in patients with normal chest radiographs may be largely caused by bronchiolitis. The observations of sequential peak flow rate measurement showed that severe pulmonary dysfunction continued for 4-5 days after the onset of the rash. To avoid the development of respiratory failure, patients with measles should be carefully monitored for bacterial superinfections of the respiratory tract especially within several days after the appearance of the rash.
Insights
Adult measles can cause severe pulmonary complications, including hypoxemia, even with normal chest X-rays, often due to bronchiolitis. Close monitoring for respiratory issues and superinfections is crucial.
Area of Science:
- Pulmonology
- Infectious Diseases
- Virology
Context:
- Adult measles presents unique clinical challenges.
- Pulmonary complications are a significant concern in adult measles patients.
- Understanding the specific manifestations of measles-related lung issues is vital for effective management.
Purpose:
- To evaluate the clinical features of pulmonary complications in adult measles patients.
- To identify key indicators of respiratory distress and dysfunction.
- To correlate clinical findings with pulmonary function test results.
Summary:
- Fifteen adult measles patients were studied; 12 required hospitalization due to fever, anorexia, and dyspnea.
- Thrombocytopenia and elevated liver enzymes were common. Hypoxemia (66.7%) occurred frequently, often without pulmonary infiltrates on chest X-rays.
- Pulmonary function tests revealed obstructive patterns, suggesting bronchiolitis as a cause of hypoxemia. Severe dysfunction persisted for 4-5 days post-rash.
Impact:
- Hypoxemia in adult measles may stem from bronchiolitis, even with clear chest radiographs.
- Early detection and management of pulmonary dysfunction are critical.
- Vigilant monitoring for bacterial superinfections is recommended to prevent respiratory failure.
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