Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Influence of PEEP on left ventricular diastolic function].

M Satoh1, J Takeda, T Yamada

  • 1Department of Anesthesiology, School of Medicine, Keio University, Tokyo.

Masui. the Japanese Journal of Anesthesiology
|September 11, 1999
PubMed
Summary

Positive end-expiratory pressure (PEEP) may impair left ventricular diastolic function by decreasing preload and increasing diastolic stiffness. This study in dogs suggests PEEP reduces cardiac compliance, potentially affecting heart performance.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A novel genetic and morphologic phenotype of ARID2-mediated myelodysplasia.

Leukemia·2017
Same author

Donor cell-derived transient abnormal myelopoiesis as a specific complication of umbilical cord blood transplantation.

Bone marrow transplantation·2017
Same author

Frequent somatic mutations in epigenetic regulators in newly diagnosed chronic myeloid leukemia.

Blood cancer journal·2017
Same author

Feasibility of salvage cord blood transplantation following fludarabine, melphalan and low-dose TBI for graft rejection after hematopoietic stem cell transplantation.

Bone marrow transplantation·2016
Same author

Active and passive exposure to tobacco smoke in relation to insulin sensitivity and pancreatic β-cell function in Japanese subjects.

Diabetes & metabolism·2014
Same author

Screening of diabetes of youth for hepatocyte nuclear factor 1 mutations: clinical phenotype of HNF1β-related maturity-onset diabetes of the young and HNF1α-related maturity-onset diabetes of the young in Japanese.

Diabetic medicine : a journal of the British Diabetic Association·2014

Area of Science:

  • Cardiology
  • Physiology
  • Mechanical Ventilation

Context:

  • Positive end-expiratory pressure (PEEP) is commonly used in mechanical ventilation.
  • Its effects on cardiac function, particularly left ventricular diastolic function, require further elucidation.
  • Understanding these effects is crucial for optimizing ventilator settings in critically ill patients.

Purpose:

  • To investigate the impact of PEEP on left ventricular diastolic function.
  • To analyze changes in diastolic interval time constant and diastolic stiffness constant under PEEP.
  • To explore the underlying mechanisms, including preload changes and intrapleural pressure effects.

Summary:

  • PEEP at 15 cmH2O significantly shortened the diastolic interval time constant in canine left ventricles.

Related Experiment Videos

  • Diastolic stiffness constant was prolonged under PEEP, suggesting impaired ventricular relaxation and increased stiffness.
  • These changes are attributed to decreased preload and increased intrapleural pressure compressing the heart.

    • Impact:

    • PEEP-induced alterations in diastolic function may lead to impaired left ventricular performance.
    • Findings highlight the importance of considering PEEP's effects on cardiac mechanics.
    • This research contributes to a better understanding of ventilator-induced cardiopulmonary interactions.