[Evaluation of selected cellular immunity parameters in patients with seasonal allergic rhinitis]

The aim of the study was the estimation of selected parameters of cellular immunity in patients with seasonal allergic rhinitis and also the estimation of histamine effect on T lymphocytes. The study comprised 240 persons--180 patients with seasonal allergic rhinitis, 30 patients with nonallergic rhinitis (positive control group) and 30 healthy persons (negative control group). In all persons the following examinations were carried on: allergic skin tests, serum level of IgE, Multitest CMI, percentage of lymphocytes T (CD3), percentage of lymphocytes T helper (CD4), percentage of lymphocytes T cytotoxic (CD8) and influence of histamine on T lymphocytes in vitro. The analysis of acquired results suggests that the inflammatory changes in patients with seasonal allergic rhinitis arose from hypofunction of T lymphocytes, especially of lymphocytes T cytotoxic (CD8) in their reaction with histamine.