Related Experiment Videos
Lymphocyte glutathione levels in acute leukemia
V Singh Ghalaut1, S Kharb, P S Ghalaut
1Department of Biochemistry, Postgraduate Institute of Medical Sciences, Rohtak, India.
Clinica Chimica Acta; International Journal of Clinical Chemistry
|September 11, 1999
Summary
Glutathione levels in lymphocytes are significantly elevated in acute leukemia patients compared to controls. Higher levels correlate with active disease, suggesting glutathione may indicate leukemic activity and relapse risk.
Area of Science:
- Biochemistry
- Hematology
- Oncology
Background:
- Glutathione protects cells from oxidative stress, crucial for hematopoietic system function.
- Altered glutathione levels are implicated in various diseases, including cancers.
Purpose of the Study:
- To investigate glutathione levels in lymphocytes of acute leukemia patients.
- To correlate these levels with disease status and chemotherapy response.
Main Methods:
- Lymphocyte glutathione levels were measured in 20 acute leukemia patients before and after chemotherapy.
- A control group of 20 healthy volunteers was included for comparison.
Main Results:
- Acute myeloid leukemia patients showed nearly double the glutathione levels compared to controls (P<0.001).
- Acute lymphoid leukemia patients exhibited 2.5 times higher glutathione levels than controls.
- Lymphocyte glutathione levels were significantly higher during active disease phases than in remission.
Conclusions:
- Lymphocyte glutathione levels can serve as a marker for leukemic activity.
- Elevated glutathione may help predict the onset of relapse in leukemia patients.
- Glutathione level alone is not the sole determinant of chemotherapy response.