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The role of autosomal cell apoptosis regulator genes in human spermatogenesis
W W Lin1, D J Lamb, L I Lipshultz
1Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA.
International Urology and Nephrology
|September 11, 1999
Abstract:
Immunohistochemical analysis of the expression of the autosomal apoptosis regulator genes, BAX, bcl-2, p53, and cyclic-AMP responsive element modulator (CREM) in testis biopsies from infertile men demonstrated that BAX, bcl-2, and p53 immunoreactivity was absent irrespective of seminiferous tubule histology. In contrast, cell-specific CREM immunoreactivity in round spermatids, with complete absence of CREM in patient biopsies showing spermatocyte maturation arrest and Sertoli cell only, was evident, suggesting a possible role of autosomal genes in the regulation of apoptosis in human spermatogenesis regulation.