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Teratogenic evaluation of oxacillin
A E Czeizel1, M Rockenbauer, H T Sørensen
1WHO Collaborating Centre for the Community Control of Hereditary Diseases, Department of Human Genetics and Teratology, National Center for Epidemiology, Budapest, Hungary.
Scandinavian Journal of Infectious Diseases
|September 11, 1999
Summary
This study found no evidence that oxacillin causes birth defects in humans. Researchers analyzed data from over 22,000 infants with abnormalities and 38,000 controls, finding no increased risk with oxacillin exposure during pregnancy.
Area of Science:
- Medical research
- Pharmacology
- Teratology
Background:
- Limited human data exists on the teratogenic potential of oxacillin.
- Oxacillin is an antibiotic used during pregnancy.
Purpose of the Study:
- To investigate the potential teratogenic risk of oral oxacillin exposure during pregnancy in humans.
Main Methods:
- A large population-based case-control study was conducted using data from the Hungarian Case-Control Surveillance of Congenital Abnormalities (1980-1996).
- The study included 22,865 fetuses/newborns with congenital abnormalities and 38,151 matched controls.
- Maternal treatment with oral oxacillin during pregnancy was assessed for cases and controls.
Main Results:
- Mothers of 14 cases and 19 controls reported oral oxacillin treatment during pregnancy.
- No statistically significant increased teratogenic risk associated with oxacillin use was detected.
Conclusions:
- This case-control study did not identify a teratogenic risk for oxacillin in humans.
- Further research may be warranted, but current findings suggest oxacillin is likely safe during pregnancy.