Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Recent developments in breast cancer therapy.

G N Hortobagyi1, M C Hung, A U Buzdar

  • 1Department of Breast Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.

Seminars in Oncology
|September 11, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genomic characterization of HER2-positive breast cancer and response to neoadjuvant trastuzumab and chemotherapy-results from the ACOSOG Z1041 (Alliance) trial.

Annals of oncology : official journal of the European Society for Medical Oncology·2017
Same author

Risk of acute myeloid leukemia and myelodysplastic syndrome among older women receiving anthracycline-based adjuvant chemotherapy for breast cancer on Modern Cooperative Group Trials (Alliance A151511).

Breast cancer research and treatment·2016
Same author

Which threshold for ER positivity? a retrospective study based on 9639 patients.

Annals of oncology : official journal of the European Society for Medical Oncology·2014
Same author

Pathologic complete response to neoadjuvant chemotherapy with trastuzumab predicts for improved survival in women with HER2-overexpressing breast cancer.

Annals of oncology : official journal of the European Society for Medical Oncology·2013
Same author

Randomized phase II non-inferiority study (NO16853) of two different doses of capecitabine in combination with docetaxel for locally advanced/metastatic breast cancer.

Annals of oncology : official journal of the European Society for Medical Oncology·2011
Same author

Role of biologic therapy and chemotherapy in hormone receptor- and HER2-positive breast cancer.

Annals of oncology : official journal of the European Society for Medical Oncology·2009
Same journal

A systematic scoping review of cancer-related anemia treatment: Comparative trial outcomes, current guidelines, and future perspectives.

Seminars in oncology·2026
Same journal

Steroid-induced tumor lysis syndrome in solid tumors: A case report and review of the literature.

Seminars in oncology·2026
Same journal

PSMA PET/CT staging in intermediate-risk prostate cancer: Toward risk-adapted implementation.

Seminars in oncology·2026
Same journal

Angiogenesis and the corresponding antiangiogenic therapy in gastroenteropancreatic neuroendocrine neoplasms.

Seminars in oncology·2026
Same journal

Post-translational regulation of steroidogenesis and its clinical relevance in hormone responsive cancers.

Seminars in oncology·2026
Same journal

Physics-informed machine learning for tumor microenvironment-responsive nanomedicine: Recent updates.

Seminars in oncology·2026
See all related articles

Advances in breast cancer treatment include improved early diagnosis and targeted therapies. Research focuses on novel interventions like HER-2/neu antibodies and angiogenesis inhibitors to enhance treatment efficacy and reduce mortality.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Over 30 years, breast cancer management has advanced through improved locoregional therapy and early diagnosis.
  • Mammography screening reduces breast cancer mortality by 25-30%, enabling optimal breast-conserving treatments.
  • Enhanced understanding of breast cancer biology has led to effective adjuvant cytotoxic and hormonal therapies, reducing mortality by 15-25%.

Purpose of the Study:

  • To review conceptual advances in breast cancer therapy.
  • To highlight progress in locoregional treatments, early diagnosis, and systemic therapies.
  • To explore emerging therapeutic strategies targeting molecular pathways and cellular processes.

Main Methods:

  • Review of conceptual approaches and therapeutic advancements in breast cancer over three decades.

Related Experiment Videos

  • Analysis of the impact of screening programs and adjuvant therapies on disease-specific mortality.
  • Examination of novel therapeutic interventions under investigation, including targeted therapies and molecular inhibitors.

    • Main Results:

    • Systematic mammography screening significantly reduces breast cancer mortality.
    • Adjuvant systemic therapies have demonstrably decreased mortality rates.
    • New therapeutic strategies targeting growth factors (e.g., HER-2/neu), signal transduction, angiogenesis, and telomerase are in development.

    Conclusions:

    • Continued progress in cytotoxic therapies is evident, with growing interest in targeted interventions.
    • Targeting growth factors, signal transduction pathways, angiogenesis, and telomerase holds promise for innovative breast cancer treatments.
    • Future research aims to improve the specificity and therapeutic index of anticancer treatments through novel molecular approaches.