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Inhibition of influenza virus replication by nitric oxide
G F Rimmelzwaan1, M M Baars, P de Lijster
1National Influenza Center, Department of Virology, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands. rimmelzwaan@viro.fgg.eur.nl
Journal of Virology
|September 11, 1999
Abstract:
Nitric oxide (NO) has been shown to contribute to the pathogenesis of influenza virus-induced pneumonia in mouse models. Here we show that replication of influenza A and B viruses in Mabin Darby canine kidney cells is severely impaired by the NO donor, S-nitroso-N-acetylpenicillamine. Reduction of productively infected cells and virus production proved to correlate with inhibition of viral RNA synthesis, indicating that NO affects an early step in the replication cycle of influenza viruses.