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Inappropriate antidiuretic hormone secretion after high-dose thiotepa
1Divisione Ematologia, Istituto di Semeiotica Medica, Università Cattolica Sacro Cuore, Rome, Italy.
Bone Marrow Transplantation
|September 14, 1999
Abstract:
High-dose thiotepa has been successfully included in a variety of conditioning regimens for stem cell transplantation in hematological and solid neoplasms. Toxicity of high-dose thiotepa mainly manifests as profound myeloablation and some degree of liver damage. We report a case of inappropriate secretion of antidiuretic hormone (SIADH) in a patient with primary CNS lymphoma who underwent therapy with high-dose thiotepa.