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[Autoimmune polyglandular syndrome].

M Inaba1

  • 1Second Department of Internal Medicine, Osaka City University Medical School.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|September 14, 1999
PubMed
Summary
This summary is machine-generated.

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Autoimmune polyglandular syndrome (APS) is an inherited cause of hypoparathyroidism, often presenting by age 20. Early signs include candidiasis, with hypoparathyroidism preceding Addison's disease.

Area of Science:

  • Endocrinology
  • Genetics
  • Immunology

Context:

  • Autoimmune polyglandular syndrome (APS) is an inherited disorder.
  • APS involves hypofunction of multiple endocrine glands.
  • Key features include candidiasis, pernicious anemia, and vitiligo.

Purpose:

  • To describe the characteristics of inherited hypoparathyroidism within APS.
  • To highlight the typical age of onset and presenting symptoms.
  • To elucidate the relationship between hypoparathyroidism and Addison's disease in APS.

Summary:

  • Inherited hypoparathyroidism in APS typically manifests by age 20.
  • Candidiasis is often the initial symptom among APS type I components.
  • Hypoparathyroidism generally precedes Addison's disease, though glucocorticoids can precipitate hypocalcemia.

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Impact:

  • Enhances understanding of APS as a cause of hypoparathyroidism.
  • Aids in early diagnosis and management of APS.
  • Informs clinical awareness regarding potential masking of hypoparathyroidism by Addison's disease treatments.