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The effects of immunosuppression on the induction and immunogenicity of chemically induced sarcomas
J C Fisher1, R C Davis, J A Mannick
1Department of Surgery, Boston University School of Medicine, Mass., USA.
The induction of chemically induced sarcomas does not appear to be accelerated by immunosuppression with antilymphocyte serum. Tumors induced in immunosuppressed mice contain tumor-specific transplantation antigens of antigenic strength comparable to that of those produced in normal hosts. Transplanted tumors will appear and grow more quickly in ALS-treated mice. Moreover, ALS pretreatment can block the recognition of and response to tumor-specific transplantation antigens.
The induction of chemically induced sarcomas does not appear to be accelerated by immunosuppression with antilymphocyte serum. Tumors induced in immunosuppressed mice contain tumor-specific transplantation antigens of antigenic strength comparable to that of those produced in normal hosts. Transplanted tumors will appear and grow more quickly in ALS-treated mice. Moreover, ALS pretreatment can block the recognition of and response to tumor-specific transplantation antigens.