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Related Experiment Videos

Glutamine as an immunoenhancing nutrient.

H Saito1, S Furukawa, T Matsuda

  • 1Surgical Center, Faculty of Medicine, University of Tokyo, Japan.

JPEN. Journal of Parenteral and Enteral Nutrition
|September 14, 1999
PubMed
Summary
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Glutamine supplementation enhances neutrophil function, improving bacterial clearance and patient outcomes during surgical stress. This nutrient supports immune cell activity, crucial for fighting severe infections in critical illness and trauma.

Area of Science:

  • Immunonutrition
  • Cellular Immunology
  • Surgical Metabolism

Background:

  • Glutamine is a key nutrient for immune cells and enterocytes.
  • Exogenous glutamine supports lymphocyte, macrophage, and neutrophil functions.
  • Neutrophils utilize glutamine significantly, impacting their functional capacity.

Purpose of the Study:

  • To investigate the effects of glutamine on neutrophil function, particularly in the context of surgical stress.
  • To evaluate glutamine's role in enhancing bacterial clearance and patient outcomes.

Main Methods:

  • Animal models of peritonitis and surgical stress were used to assess bacterial clearance and outcomes with glutamine administration.
  • In vitro studies examined the impact of glutamine on neutrophils from postoperative patients.

Related Experiment Videos

  • Assays measured phagocytosis and reactive oxygen intermediate (ROI) production by neutrophils.

    • Main Results:

    • Enteral glutamine improved bacterial clearance in a rat peritonitis model.
    • Intravenous glutamine supplementation enhanced outcomes in animals experiencing severe surgical stress.
    • In vitro, glutamine increased neutrophil phagocytosis and dose-dependently augmented ROI production, enhancing bacterial killing in postoperative patients.

    Conclusions:

    • Glutamine plays a critical role in maintaining neutrophil function.
    • Supplementation with glutamine may improve the bactericidal capacity of neutrophils.
    • Glutamine shows potential for preventing and treating severe infections in critical illness and trauma patients.