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Nucleotides and intestine.

T Tsujinaka1, M Kishibuchi, S Iijima

  • 1Department of Surgery II, Osaka University Medical School, Suita, Japan.

JPEN. Journal of Parenteral and Enteral Nutrition
|September 14, 1999
PubMed
Summary
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Parenteral nucleic acid supplementation supports intestinal health. Supplementing with nucleotides and nucleosides improved mucosal growth, barrier function, and cell proliferation in rats receiving parenteral nutrition.

Area of Science:

  • Gastroenterology
  • Nutrition Science
  • Cell Biology

Background:

  • Dietary nucleotides are crucial for intestinal growth and development.
  • Parenteral nutrition (PN) may necessitate nucleic acid supplementation to maintain intestinal mucosal integrity.
  • Maintaining mucosal proliferation and barrier functions is vital during PN.

Purpose of the Study:

  • To investigate the effects of parenteral nucleotide and nucleoside supplementation on intestinal mucosal health in rats.
  • To evaluate the impact of OG-6 (nucleotide and nucleoside mixture) on jejunal mucosa compared to standard PN.

Main Methods:

  • Male Wistar rats were assigned to three groups: FED (ad libitum feeding), PN (standard parenteral nutrition), and OG (PN with OG-6).
  • Evaluated parameters included mucosal weight, protein, DNA, villous height, crypt depth, intercellular junctions, cell proliferation, permeability, bacterial translocation, and cathepsin activity.

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Main Results:

  • OG group showed significantly increased jejunal mucosal weight, protein, and DNA content compared to the PN group.
  • Nucleic acid supplementation enhanced villous height and intercellular junction integrity, and increased cell proliferation markers.
  • The OG group exhibited improved intestinal barrier function, indicated by reduced fluorescein isothiocyanate-dextran translocation and lactulose excretion.

Conclusions:

  • Parenteral supplementation with nucleic acids effectively supports intestinal mucosal cell proliferation.
  • Nucleic acid supplementation enhances intestinal mucosal barrier functions during parenteral nutrition.
  • This strategy is beneficial for maintaining gut health in patients receiving PN.