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Related Experiment Videos

Patterning of somatosympathetic reflexes.

I A Kerman1, B J Yates

  • 1Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.

The American Journal of Physiology
|September 14, 1999
PubMed
Summary

Different somatic inputs activate distinct sympathetic nerve patterns. Skin and muscle stimulation elicit unique sympathetic outflow distinct from vestibular reflexes, with responses varying based on animal preparation and blood pressure.

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Area of Science:

  • Neuroscience
  • Autonomic Nervous System
  • Somatic Reflexes

Background:

  • Previous research identified specific sympathetic nerve activation patterns from vestibular nerve stimulation in cats.
  • Vestibulosympathetic reflexes showed consistent patterns in both anesthetized and decerebrate preparations.

Purpose of the Study:

  • To investigate sympathetic outflow patterns elicited by skin and muscle afferent inputs.
  • To compare these patterns with those generated by vestibular stimulation.
  • To examine the influence of anesthesia and baroreceptor status on somatosympathetic responses.

Main Methods:

  • Stimulation of forelimb and hindlimb nerves (skin and muscle afferents) in cats.
  • Measurement of sympathetic nerve activation in various efferent nerves (renal, superior mesenteric, lumbar colonic, external carotid, hypogastric).
Keywords:
NASA Discipline NeuroscienceNon-NASA Center

Related Experiment Videos

  • Comparison of responses in anesthetized versus decerebrate preparations.
  • Assessment of responses under different blood pressure conditions in baroreceptor-intact animals.

    • Main Results:

    • Skin and muscle inputs produced a distinct sympathetic outflow pattern compared to vestibular stimulation.
    • Renal, superior mesenteric, and lumbar colonic nerves showed strong activation (approx. 60%) to limb nerve stimulation.
    • External carotid and hypogastric nerves showed weaker activation (approx. 20%) to limb nerve stimulation.
    • Somatosympathetic responses differed between anesthetized and decerebrate animals.
    • Elevated blood pressure (>150 mmHg) in baroreceptor-intact animals strongly attenuated somatosympathetic responses (<20% of control).

    Conclusions:

    • Different somatic inputs (vestibular vs. skin/muscle) activate distinct sympathetic nerve patterns.
    • These distinct patterns are likely mediated by separate neural circuits.
    • Anesthesia and baroreceptor reflexes modulate the expression of somatosympathetic responses.