Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pupillary responses evoked during verbal fluency tasks indicate semantic network dysfunction in schizophrenia.

E Granholm1, D Chock, S Morris

  • 1Department of Psychiatry, University of California, San Diego, USA. egranholm@ucsd.edu

Journal of Clinical and Experimental Neuropsychology
|September 15, 1999
PubMed
Summary

Patients with schizophrenia exhibit word retrieval deficits and increased cognitive load during semantic fluency tasks. This suggests impaired automatic semantic memory processes, impacting frontal lobe functions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Recombination effects in laser-driven acceleration of heavy ions.

Physical review. E·2025
Same author

Estimating population mental health effects of the rollout of Universal Credit in the UK using standard and novel Difference-in-Differences analysis, 2009-2019.

Public health·2025
Same author

Assessment of increased General Practitioner access to diagnostic imaging.

Irish medical journal·2025
Same author

Designing AI-powered healthcare assistants to effectively reach vulnerable populations with health care services: A discrete choice experiment among South African university students.

medRxiv : the preprint server for health sciences·2025
Same author

Management of fetal cardiac resuscitation during fetal cardiac intervention.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2024
Same author

Laparoscopic cholecystectomy performed by a surgical care practitioner: a review of outcomes.

Annals of the Royal College of Surgeons of England·2024

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Psychiatry

Background:

  • Schizophrenia is associated with cognitive deficits, including impaired word retrieval.
  • Pupillary responses are a validated measure of cognitive processing load.

Purpose of the Study:

  • To investigate controlled search and automatic semantic network deficits in schizophrenia using pupillary responses during fluency tasks.
  • To examine the relationship between word retrieval, cognitive load, and brain function in schizophrenia.

Main Methods:

  • Pupillary responses were recorded during semantic and phonemic fluency tasks.
  • Word retrieval performance was compared between patients with schizophrenia and nonpsychiatric participants.
  • Pupillary dilation patterns were analyzed in relation to task type and trial duration.

Related Experiment Videos

Main Results:

  • Word retrieval was more impaired in semantic than phonemic fluency tasks in patients, particularly within the first 15 seconds.
  • Nonpsychiatric participants showed greater pupillary dilation during phonemic fluency, whereas patients showed greater dilation during semantic fluency.
  • These findings indicate increased cognitive demand on controlled search processes in patients during semantic fluency.

Conclusions:

  • Patients with schizophrenia demonstrate deficits in automatic semantic memory processes.
  • Schizophrenia involves impaired frontal lobe controlled search processes, evidenced by pupillary responses.
  • Early semantic fluency impairments in schizophrenia suggest a breakdown in the temporal lobe's facilitation of word retrieval.