A human genome map of comparative anchor tagged sequences
Related Experiment Video
Updated: Oct 19, 2026

Informatic Analysis of Sequence Data from Batch Yeast 2-Hybrid Screens
Published on: June 28, 2018
Z Q Chen1, J A Lautenberger, L A Lyons
1Intramural Research Support Program, SAIC Frederick, National Cancer Institute, Maryland, USA.
Abstract:
Effective comparative mapping inference utilizing developing gene maps of animal species requires the inclusion of anchored reference loci that are homologous to genes mapped in the more "gene-dense" mouse and human maps. Nominated anchor loci, termed comparative anchor tagged sequences (CATS), have been ordered in the mouse linkage map, but due to the dearth of common polymorphisms among human coding genes have not been well represented in human linkage maps. We present here an ordered framework map of 314 comparative anchor markers in humans based on mapping analysis in the Genebridge 4 panel of radiation hybrid cell lines, plus empirically optimized CATS PCR primers which detect these markers. The ordering of these homologous gene markers in human and mouse maps provides a framework for comparative gene mapping of representative mammalian species.
More Related Videos
Related Concept Videos
Genome Annotation and Assembly
Evolutionary Relationships through Genome Comparisons
Karyotyping
Genomics
Genomic DNA in Eukaryotes
Multi-species Conserved Sequences
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved DNA...

