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Verbal memory impairment after left insular cortex infarction.

F Manes1, J Springer, R Jorge

  • 1Department of Psychiatry, University of Iowa College of Medicine, Iowa City, Iowa, USA. ffm21@cam.ac.uk

Journal of Neurology, Neurosurgery, and Psychiatry
|September 16, 1999
PubMed
Summary
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Left insular cortex damage impairs verbal memory. This study found patients with left insular infarction performed significantly worse on immediate and delayed verbal memory tests compared to those with right insular infarction.

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Neurology

Background:

  • Positron Emission Tomography (PET) studies suggest a link between insular cortex blood flow and verbal memory.
  • The insular cortex's role in verbal memory requires further investigation.

Purpose of the Study:

  • To compare verbal memory performance in patients with right versus left insular infarction.
  • To determine if the location of insular damage influences verbal memory deficits.

Main Methods:

  • Compared verbal memory profiles of two groups of right-handed stroke patients: four with right insular infarction and six with left insular infarction.
  • Administered standardized verbal memory tests (WMS-R logical memory I and II, CERAD word list memory) 4-8 weeks post-stroke.
  • Ensured patient groups were comparable for age, education, and sex.

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Main Results:

  • Patients with left insular lesions demonstrated significantly poorer immediate and delayed verbal recall.
  • Statistical analysis revealed significant differences in performance on the WMS-R logical memory I and II, and CERAD delayed recall subtests.
  • Specifically, left insular infarction was associated with impaired performance (t=-2.73, p<0.03; t=-4.1, p<0.004; t=-2.4, p<0.05).

Conclusions:

  • Left insular damage is associated with significant deficits in verbal memory.
  • These findings suggest the insula plays a crucial role in the neural network supporting verbal memory functions.
  • The lateralization of insular damage may differentially impact verbal memory capabilities.