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Monoclonal antibody MAb-170 for immunoscintigraphic detection of ovarian tumors
C Alexander1, C E Villena-Heinsen, A Schaefer
1Department of Nuclear Medicine, Saarland University Medical Center, Homburg, Germany.
Objective:
The technetium Tc 99m-labeled monoclonal antibody MAb-170 was designed for diagnostic use in patients with gynecologic adenocarcinoma. Our investigation was initiated to verify its usefulness for radioimmunoscintigraphy of ovarian tumors.
Study Design:
Most of the 82 patients participating in this study underwent immunoscintigraphy before first-look surgery.
Results:
Radioimmunoscintigraphy recognized 36 of 41 patients with adenocarcinoma of the ovaries, corresponding to an overall sensitivity of 88%. Specificity was 90% (38/42). The calculation of accuracy gave a result of 89% (74/83). Of 110 known lesions, 92 were visualized successfully; thus the local-regional sensitivity was 84%. Of 160 benign tumor sites, 154 showed no evidence of tracer accumulation, corresponding to a local-regional specificity of 96%. The smallest lesion visualized was an adenocarcinoma of the corpus uteri with a diameter of 1.5 cm.
Conclusion:
The monoclonal antibody MAb-170 is a promising radiopharmaceutical for immunoscintigraphy of ovarian adenocarcinoma.