Basosquamous carcinoma after ultraviolet therapy with artificial sunlight

Area of Science:

• Dermatology
• Oncology

Background:

• Ultraviolet (UV) radiation is a known carcinogen.
• Therapeutic UV exposure, including artificial sources, requires careful risk assessment.

Observation:

• A 63-year-old man developed basosquamous carcinoma on his leg.
• The cancer arose after 30 sessions of artificial sunlight therapy over 3 years for a prior eczematous lesion.
• Histopathology revealed features of both basal cell carcinoma and squamous cell carcinoma.

Findings:

• The case presents a rare instance of basosquamous carcinoma following non-photochemotherapy ultraviolet therapy.
• Histological analysis showed atypical cells with nuclear palisading and squamous differentiation.
• The development is hypothesized to stem from artificial sunlight-induced solar keratosis.

Implications:

• This report suggests a potential link between artificial sunlight therapy and basosquamous carcinoma development.
• It underscores the need for vigilance regarding skin cancer risks associated with non-standard UV treatments.
• Further research may be warranted to evaluate the oncogenic potential of various artificial UV sources.