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Sneddon's syndrome and antithrombin III.

E Bolayir¹, H Keçeci, M Akyol

¹Department of Neurology, Cumhuriyet University, Sivas, Turkey.

The Journal of Dermatology

|September 16, 1999

Summary

Sneddon's syndrome is a rare cerebrovascular disorder. This study presents two cases with increased antithrombin III levels, highlighting a potential link to this condition.

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Area of Science:

Neurology
Vascular Medicine
Rheumatology

Background:

Sneddon's syndrome is a rare, idiopathic condition characterized by recurrent cerebrovascular accidents and livedo reticularis.
The exact pathophysiology remains unclear, but thrombotic events are a key feature.

Observation:

This report details two patients diagnosed with Sneddon's syndrome.
Both patients presented with clinical features consistent with the syndrome.
Notably, both individuals exhibited elevated antithrombin III levels.

Findings:

The presence of increased antithrombin III was a significant finding in both Sneddon's syndrome cases.
This suggests a potential association between hypercoagulability, indicated by elevated antithrombin III, and the development of Sneddon's syndrome.

Implications:

Understanding the role of antithrombin III in Sneddon's syndrome may lead to improved diagnostic approaches.
Further research into hypercoagulable states could elucidate the underlying mechanisms of Sneddon's syndrome.
This finding may inform future therapeutic strategies for patients with Sneddon's syndrome and related thrombotic disorders.

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