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The Physical Activity for Total Health (PATH) Study: rationale and design
A McTiernan1, C M Ulrich, D Yancey
1Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. amctiern@fhcrc.org
Medicine and Science in Sports and Exercise
|September 16, 1999
Summary
Regular physical activity may lower breast cancer risk in postmenopausal women by influencing sex hormones. This study investigated the impact of a moderate-intensity exercise program on hormone levels and related health markers.
Area of Science:
- Endocrinology
- Exercise Physiology
- Oncology
Background:
- Physical activity is linked to reduced breast cancer risk, potentially through hormonal pathways.
- Understanding these mechanisms is crucial for preventative strategies.
Purpose of the Study:
- To investigate the effect of a 1-year moderate-intensity physical activity intervention on the endogenous sex hormone profile of postmenopausal women.
- To explore potential mechanisms linking physical activity to breast cancer risk reduction.
Main Methods:
- 168 sedentary postmenopausal women (55-75 years) with BMI ≥ 25.0 were randomized.
- Intervention group: 1-year moderate-intensity aerobic and strength training.
- Control group: Stretching classes.
Main Results:
- Serum hormones (estrone, estradiol, testosterone, etc.), insulin, glucose, and triglycerides were measured.
- Estrogen metabolite ratio (2-hydroxyestrone:16alpha-hydroxyestrone) was assessed.
- Body composition and fat distribution were evaluated using various methods.
Conclusions:
- This is the first study to examine physical activity's impact on sex hormones in postmenopausal women.
- Findings will offer insights into how physical activity may reduce breast cancer risk.