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Chrysosporium parvum keratomycosis.
M D Wagoner1, I A Badr, A A Hidayat
1Anterior Segment/External Disease Division, King Khaled Eye Specialist Hospital, Kingdom of Saudi Arabia. kkeshres@naseej.com
Cornea
|September 16, 1999
Summary
This case report details the first instance of Chrysosporium parvum causing fungal keratitis, a serious corneal infection. Prompt diagnosis and treatment were crucial for managing this rare ocular fungal disease.
Area of Science:
- Ophthalmology
- Medical Mycology
- Infectious Diseases
Background:
- Ocular infections caused by filamentous fungi can lead to severe vision impairment.
- Chrysosporium species are typically associated with pulmonary infections, rarely presenting as a cause of keratitis.
Observation:
- A 43-year-old man presented with corneal stromal infiltrate and perforation of the left eye.
- Diagnosis was established through corneal scrapings, histopathology, and microbiologic isolation.
- Recurrent keratitis at the graft-host junction necessitated repeat diagnostic and therapeutic interventions.
Findings:
- Histopathology revealed septate hyphae with endospores, indicative of filamentous keratomycosis.
- Microbiologic culture confirmed the presence of Chrysosporium parvum.
- Recurrent infection showed identical diagnostic findings.
Implications:
- This case highlights Chrysosporium parvum as a potential pathogen in human fungal keratitis.
- It underscores the importance of considering unusual fungal agents in refractory or recurrent cases of keratomycosis.
- Early and accurate diagnosis is essential for appropriate antifungal therapy and visual preservation.