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Morphologic study of microcirculation in acromegaly by capillaroscopy.

F Schiavon1, P Maffei, C Martini

  • 1Department of Medical and Surgical Sciences, Padua University, Padova, Italy.

The Journal of Clinical Endocrinology and Metabolism
|September 16, 1999
PubMed
Summary

Acromegaly patients show altered nailfold microcirculation, with reduced capillary density and increased tortuosity. These changes improve with disease remission, suggesting nailfold capillaroscopy aids acromegaly monitoring.

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Area of Science:

  • Endocrinology
  • Vascular Biology
  • Dermatology

Background:

  • Acromegaly is associated with cardiovascular complications, but microcirculatory changes are understudied.
  • Nailfold capillaroscopy offers in vivo visualization of the cutaneous vascular bed.

Purpose of the Study:

  • To investigate nailfold capillaroscopy findings in acromegaly patients.
  • To correlate microcirculatory morphology with disease activity and hormonal parameters.

Main Methods:

  • Nailfold capillaroscopy using computer-aided stereomicroscopy (x400) in 25 acromegalic patients and 26 controls.
  • Assessment of capillary number, length, tortuosity, meandering capillaries, avascular areas, and subpapillary plexus visibility.
  • Comparison between active disease, stable remission, and control groups.

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Main Results:

  • Acromegalic patients exhibited significantly reduced capillary number and length compared to controls.
  • Increased tortuous and meandering capillaries were observed in acromegalics.
  • Improved capillaroscopic morphology was noted in patients with stable disease remission versus active disease.

Conclusions:

  • Acromegaly induces significant morphological alterations in peripheral microcirculation.
  • Microcirculatory changes are linked to disease activity.
  • Nailfold capillaroscopy is a valuable tool for monitoring acromegaly patients.