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Updated: Jul 11, 2026

An Improved Method for the Preparation of Type I Collagen From Skin
Published on: January 21, 2014
Morphometric analysis of collagen: a comparative study in cow and pig skins
A Kobayashi1, K Takehana, Eerdunchaolu
1Department of Veterinary Anatomy, School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido, Japan.
Abstract:
Light and electron microscopic studies were conducted on dermis samples taken from different regions of adult cows and pigs to determine whether there is a correlation between subfibrillar architecture and collagen fibril diameter in dermis tissue. Dermis thicknesses, collagen fibril diameters, subfibrillar architecture diameters, and angles of the helical arrangement of subfibrillar architectures were measured in all dermis samples. The results showed that the differences between subfibrillar architecture diameters in dermis samples from different regions of the same species were not significant and that the diameters of subfibrillar architectures in dermis samples were similar (22-28 nm) in the two species (cow and pig) examined in this study. These findings therefore suggest that the collagen fibril diameter depends on the number of subfibrillar architectures in each fibril.
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