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Related Experiment Videos

Bronchial mucosal permeability.

J C Hogg, P D Paré, R C Boucher

    Federation Proceedings
    |February 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    In allergic asthma, inhaled allergens trigger rapid lung changes by activating superficial mast cells and increasing airway permeability. This allows more histamine to reach airway smooth muscle, causing hyperresponsiveness.

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    Area of Science:

    • Pulmonary immunology
    • Allergic airway inflammation
    • Epithelial barrier function

    Background:

    • The tracheobronchial epithelium's tight junctions suggest resistance to protein penetration.
    • Allergic asthma involves rapid pulmonary changes after antigen inhalation.
    • Mast cells are present in the bronchial lumen and epithelium.

    Purpose of the Study:

    • To investigate the mechanisms behind rapid pulmonary changes in Ascaris-allergic monkeys.
    • To explore the role of mast cells and epithelial tight junctions in allergic airway responses.
    • To understand increased airway hyperresponsiveness following antigen challenge.

    Main Methods:

    • Antigen inhalation challenge in Ascaris-allergic monkeys.
    • Assessment of pulmonary physiologic changes.

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  • Measurement of epithelial permeability to proteins and histamine.
  • Evaluation of airway responsiveness to histamine.

    • Main Results:

    • Antigen inhalation caused rapid pulmonary changes and increased epithelial permeability to protein.
    • Antigen challenge led to increased permeability to labeled histamine.
    • Airway hyperresponsiveness to histamine was observed after antigen challenge.
    • Alterations in tight junctions are suggested to cause increased permeability.

    Conclusions:

    • Antigen-antibody interaction on superficial mast cells initiates mediator release and receptor stimulation.
    • Increased epithelial permeability, due to tight junction alterations, contributes to allergic airway responses.
    • Damage to epithelial tight junctions may explain histamine-induced airway hyperreactivity seen in various conditions.