Complications and costs of treatment of refractory generalized convulsive status epilepticus in children

Multiple case series in the literature suggest that benzodiazepines and barbiturates are highly efficacious at stopping seizures. Apparent differences in mortality might not be due solely to drug effect. In this systematic review of the medical literature, we assessed the complications and costs of treatment of refractory status epilepticus in 111 children who met strict inclusion criteria, as part of an effort to provide an evidenced-based recommendation for optimal therapy. All children treated with barbiturates required mechanical ventilation, versus 13% of patients treated with benzodiazepines. Benzodiazepine treatment was associated with pressor use in 3.5% of cases, versus 35% with barbiturate treatment. Midazolam treatment was for the shortest duration and allowed the most rapid return to consciousness. Differences in mean 24-hour drug costs were small compared to savings produced by shorter length of treatment and return to consciousness. Benzodiazepines appear to have higher drug costs but lower complications and overall costs than barbiturates.